Renal Denervation
A specialized procedure that targets overactive nerves in the kidneys to naturally lower blood pressure in patients with resistant hypertension.
Renal denervation (RDN) is a catheter-based procedure that disrupts sympathetic nerve activity around the renal arteries to lower blood pressure in patients with true resistant hypertension — those who remain hypertensive despite three or more antihypertensive medications.
Book a Consultation
Renal denervation safely disrupts the overactive sympathetic nerves surrounding the kidney arteries to lower chronically high blood pressure.
Patient Selection
- ABPM-confirmed hypertension — not white coat effect
- Medication adherence verified by clinical assessment
- Secondary causes of hypertension excluded
- Suitable renal artery anatomy — main renal artery diameter greater than 4 mm
RDN Device Platforms
- Radiofrequency-based RDN (Symplicity Spyral) — multi-electrode spiral catheter delivering targeted RF energy to the renal artery wall
- Ultrasound-based RDN (Paradise system) — balloon catheter with circumferential ultrasound transducer for broader ablation coverage
The Evidence
Pivotal clinical trials including SPYRAL HTN-OFF MED and RADIANCE-HTN TRIO demonstrate ABPM-confirmed reductions of approximately 3–5 mmHg systolic blood pressure attributable to RDN — a clinically meaningful reduction that decreases long-term cardiovascular event risk.
The Procedure
Performed under local anaesthesia via femoral artery access. Both renal arteries are treated in a single session taking 45–60 minutes. Same-day discharge is typical. Renal function is monitored at baseline and follow-up.
Expected Outcomes
Blood pressure response develops gradually over weeks to months as sympathetic nerve activity is progressively disrupted. ABPM monitoring at three and six months assesses the degree of blood pressure reduction and guides medication adjustment.
Considering Renal Denervation?
Dr. Peter Chang will assess your suitability and discuss all treatment options during a specialist consultation at Paragon Medical Centre, Singapore.